The world is desperate for new Covid-19 vaccines to be available for use quickly and traditional large scale clinical trials involving thousands of human volunteers can take many months to conduct.
Now researchers at Oxford University in the UK have developed a method to predict how well new Covid-19 vaccines will work based on a simple blood test.
The method potentially offers a shortcut around the massive clinical trials traditionally used that are becoming increasingly difficult to conduct.
Researchers and regulators around the globe are working on benchmarks which may allow slower companies in the vaccine development race to provide evidence of efficacy without having to conduct trials with tens of thousands of volunteers.
The researchers looked at the concentration of a range of virus-fighting antibodies in the blood of trial participants after they had received a vaccine developed by AstraZeneca and Oxford University, now known as Vaxzevria.
By looking at which of those trial volunteers later contracted symptomatic Covid-19 and which did not, the researchers produced a model they hope will predict how powerful other vaccines will be, based on those blood readings.
“The data can be used to extrapolate efficacy estimates for new vaccines where large efficacy trials cannot be conducted,” they said in their paper, which was posted online on Thursday and submitted for peer-review for future publication in a scientific journal.
The Oxford researchers cautioned more work was needed to validate their model for many of the highly contagious new variants.
They noted that they did not look into the so-called cellular immune response, a major weapon of the human body against infections alongside antibodies, but more difficult to measure.
“There is an urgent need to increase the supply of vaccines for the world, but development and approval of new vaccines takes many months. We hope that the use of correlates by developers and regulators could speed up the process,” said Andrew Pollard, director of the Oxford Vaccine Group and lead investigator on the Oxford Vaccine Trial.
Those mass trials have so far relied on participants to contract the disease in their normal lives to provide vaccine efficacy results. That becomes more of a challenge where vaccination coverage is already high and the virus is not circulating widely.
The traditional clinical trials also require many participants to get a placebo as a comparison to those who receive the experimental vaccine, posing an ethical dilemma where approved shots are available.