Tuesday, March 2, 2021

Moderna says Covid-19 vaccine effective against UK, South Africa variants

But the positive news was tempered by the finding that there was a sixfold reduction in the level of highly-potent neutralising antibodies produced against the South African variant.

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US biotechnology firm Moderna on Monday said lab studies showed its Covid-19 vaccine remains effective against variants of the coronavirus first identified in the UK and South Africa.

But the positive news was tempered by the finding that there was a sixfold reduction in the level of highly-potent neutralising antibodies produced against the South African variant, B.1.351.

Out of caution, the company will test adding a second booster of its vaccine – to make three shots in total – and has begun preclinical studies on a booster specifically for the South African variant.

“We are encouraged by these new data, which reinforce our confidence that the Moderna Covid-19 vaccine should be protective against these newly detected variants,” said Stephane Bancel, Moderna’s CEO.

“Out of an abundance of caution and leveraging the flexibility of our mRNA platform, we are advancing an emerging variant booster candidate against the variant first identified in the Republic of South Africa into the clinic.”

The emergence of highly contagious variants to the SARS-CoV-2 virus had triggered concern about their impact on the efficacy of Covid-19 vaccines even as countries begin to accelerate their immunization programs.

Both the B.1.1.7 variant first seen in the UK and the B.1.351 variant have multiple mutations along the “spike protein”, molecules that dot the surface of the virus and allow it to invade human cells.

Scientists have been particularly worried that the mutations on B.1.351 would lead to the virus escaping the action of antibodies, and render the current generation of vaccines obsolete.

Moderna’s vaccine uses mRNA – a type of genetic molecule – to deliver the information for human cells to create the spike protein inside the human body, in order to trigger an immune response.

A booster for B.1.351 would therefore carry the mRNA that creates the spike protein with the mutations that are specific to the variant.

A major advantage of mRNA vaccines is that they can be developed in a matter of weeks, even though producing them to mass scale may take much longer.

Reaction mixed

To study the impact of the Moderna vaccine, called mRNA-1273, the company took blood samples from eight people who had received two doses of the vaccine, and from primates that had also been immunized.

For the B.1.1.7 variant there was no impact on the level of neutralising antibodies – which bind to the spike protein and prevent it from invading human cells – that were produced by the shots.

But for the South African variant, B.1.351, there was a sixfold reduction in the neutralising antibody level.

Even so, the company said it remained above the quantity that was shown to be protective in earlier tests on primates that were infected on purpose.

Reaction to Moderna’s statement by independent experts was mixed.

Akiko Iwasaki, a leading virologist from Yale, tweeted: “This is good,” adding that she expected other vaccine makers were also developing boosters that target the South African variant.

Benjamin Neuman, a virologist from Texas A&M university, agreed and told AFP that the reduction in potency pertained to only one type of antibody, that make up 1% of the overall antibodies that bind to the spike protein of the virus, which it uses to enter cells.

“To be clear, the 99% of antibodies that bind to other parts of the spike and are not neutralising should still work just as well on the mutant strains,” he said.

He added the decrease found in the study “would be more a bellwether of potential problems to come than a sign of imminent danger”, adding that in a living person, the immune system learns to adjust the antibodies it produces if their efficiency decreases.

But Lawrence Young, a virologist at Britain’s Warwick University, said the sixfold reduction was a matter “of concern” and suggested vaccine efficacy as well as duration of protection could be impacted.

Moderna, which carried out the studies with the National Institutes of Health, has submitted the study to a preprint server so it can be analysed by the wider scientific community.

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